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KMID : 0043320080310070830
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.830 ~ p.833
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A New Lignan Glycoside from the Fruits of Cornus kousa Burg
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Lee Dae-Young
Yoo Ki-Hyun
Chung In-Sik
Kim Ju-Young
Chung Dae-Kyun
Kim Dae-Keun
Kim Sung-Hoon
Baek Nam-In
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Abstract
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A new lignan glycoside, (7’S, 8’R)-dihydrodehydrodiconiferyl alcohol-4’-O--D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, and -NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7’S, 8’R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [ (2), (3)], MCF-7 [ (2), (3)], SK-MEL-5 [ (2), (3)], and SK-OV-3 [ (2), (3)] cell lines.
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KEYWORD
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Cornus kousa, Lignan glycoside, Cornuskoside A, (-)-Balanophonin, (7’S, 8’R)-Dihydrodehydrodiconiferyl alcohol, Cytotoxicity
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